Susan M. Stalnecker Named to Bioventus Board of Managers

DURHAM, NC – October 25, 2018 – Bioventus, a global leader in orthobiologic solutions, today announced the appointment of Susan M. Stalnecker, former Vice President and Treasurer, E.I. du Pont de Nemours and Company, to the company’s Board of Managers, replacing Michael Minogue.

“Susan is joining the Bioventus Board at an exciting time as we accelerate the growth of our osteoarthritis business, expand our surgical orthobiologics business and continue to launch our products in new international markets like Brazil,” said Tony Bihl, CEO of Bioventus. “Her global financial background, experience leading audit and finance committees and leadership roles on both public company and nonprofit boards will provide us with fresh perspectives and insights to help drive our strategy to be a global leader in orthobiologics.”

“The orthobiologic space intrigues me and I believe I can help the team at Bioventus achieve their goals of bringing more solutions to market to help patients heal and return to active lifestyles,” said Stalnecker. “Clinicians and spine surgeons around the world are noticing this company and its innovations, and I am eager to guide Bioventus as it continues to grow into these markets.”

Stalnecker served as Vice President of E. I. du Pont de Nemours and Company until she retired in 2016. During her nearly 40-year career at DuPont she served in several senior leadership roles including Vice President, Treasurer & M&A; Vice President, Risk Management; Vice President-Government and Consumer Markets; and, Vice President Productivity & Shared Services.

Stalnecker served on the Board of trustees of Duke University from 2003 to 2015, and as Vice Chair from 2003-2005. She currently serves on the Board of Directors of Leidos Holdings, Inc., Board of Trustees, Optimum Fund Trust and the Board of Trustees, Duke Health System. In addition, she was a Board Director of PPL Corporation. She is also a Senior Adviser, Boston Consulting Group.

She received a bachelor’s degree from Duke University and an MBA from the Wharton School of Graduate Business at the University of Pennsylvania.

About Bioventus

Bioventus is an orthobiologics company that delivers clinically proven, cost-effective products that help people heal quickly and safely. Its mission is to make a difference by helping patients resume and enjoy active lives. The orthobiologic products from Bioventus include offerings for osteoarthritis, surgical and non-surgical bone healing. Built on a commitment to high quality standards, evidence-based medicine and strong ethical behavior, Bioventus is a trusted partner for physicians worldwide. For more information, visit www.BioventusGlobal.com and follow the company on Twitter @Bioventusglobal.

Bioventus and the Bioventus logo are registered trademarks of Bioventus LLC.

Media Contact: Thomas Hill,  , [email protected]


Bioventus Receives ANVISA Approval to Market DUROLANE in Brazil and Selects Pfizer as Exclusive Distribution Partner

HOOFDDORP, THE NETHERLANDS – October 2, 2018 – Bioventus, a global leader in orthobiologic solutions, has received approval from Agência Nacional de Vigilância Sanitária (ANVISA) to market DUROLANE, its single-injection joint-fluid osteoarthritis (OA) treatment, in Brazil. ANVISA has approved DUROLANE for the symptomatic treatment of mild to moderate knee and hip OA. In addition, Bioventus has selected Pfizer as its exclusive distribution partner for the market.

OA involves the breakdown, or degeneration, of cartilage and the synovial fluid that cushions and lubricates joint tissues. Hyaluronic acid (HA)-based products like DUROLANE, help manage pain in the knees and hips of patients with OA.

Pfizer has more than 100 sales representatives throughout Brazil and will offer DUROLANE as part of its arthritis pain management portfolio which also includes CELEBRA®, a COX-2 selective nonsteroidal anti-inflammatory drug (NSAID).

“Brazil is the largest market for patients seeking osteoarthritis pain solutions in Latin America and one of the larger markets worldwide,” said Tony Bihl, CEO of Bioventus. “Introducing DUROLANE here gives patients and physicians access to a proven pain reliever for knee OA, expands the footprint of Bioventus and underscores our continuing efforts to bring orthobiologic solutions to patients around the world.”

“We are very pleased Pfizer is adding DUROLANE to its pain management portfolio for OA patients in Brazil,” said John Nosenzo, Chief Commercial Officer, Bioventus. “The company’s sales representatives have tremendous knowledge regarding osteoarthritis pain solutions. In addition, they have deep relationships with physicians and hospitals, making this a natural fit for Bioventus.”

DUROLANE is based on a natural, safe and proven technology process called NASHA®. This process yields stabilized (HA) which is a naturally occurring molecule that provides the lubrication and cushioning in a normal joint. It has been proven to provide greater reduction in OA knee pain versus Synvisc-One®1* and longer lasting pain relief versus a steroid injection2. DUROLANE is also safe for repeated courses of therapy. Repeated use of DUROLANE does not increase the incidence of adverse events.2, 3

About Bioventus

Bioventus is an orthobiologics company that delivers clinically proven, cost-effective products that help people heal quickly and safely. Its mission is to make a difference by helping patients resume and enjoy active lives. The orthobiologic products from Bioventus include offerings for osteoarthritis, surgical and non-surgical bone healing. Built on a commitment to high quality standards, evidence-based medicine and strong ethical behavior, Bioventus is a trusted partner for physicians worldwide. For more information, visit www.BioventusGlobal.com and follow the company on Twitter @Bioventusglobal.

Bioventus, the Bioventus logo, and DUROLANE are registered trademarks of Bioventus LLC. NASHA is a registered trademark of Nestle Skin Health s.a. CELEBRA is a registered trademark of Pfizer. Synvisc-One and Synvisc are registered trademarks of Genzyme Corporation.

Media Contact: Thomas Hill,  , [email protected]

Summary of Indication for Use: Symptomatic treatment of mild to moderate knee or hip osteoarthritis. There are no known contraindications. You should not use DUROLANE if you have infections or skin disease at the injection site. DUROLANE has not been tested in pregnant or lactating women, or children. Risks can include transient pain, swelling and/or stiffness at the injection site.,Indications presented are those approved in Brazil; indications and product offerings vary by country. Consult with your local Bioventus representative for approved use within your region of interest. Full prescribing information can be found in product labeling, at www.DUROLANE.com.

References: 1. McGrath AF, McGrath AM, Jessop ZM, et al. A comparison of intra-articular hyaluronic acid competitors in the treatment of mild to moderate knee osteoarthritis. J Arthritis. 2013; 2(1):108. doi:10.4172/2167-7921.1000108. 2. Leighton R, Åkermark C, Therrien R, et. al. NASHA hyaluronic acid vs methylprednisolone for knee osteoarthritis: a prospective, multi-centre, randomized, non-inferiority trial. Osteoarthritis Cartilage. 2014; 22(1):17-25. 3. DUROLANE [package insert]. Durham, NC: Bioventus LLC; 2017.