Larry Chen Joins Bioventus as Managing Director, China and Asia Pacific

DURHAM, NC – March 4, 2021 – Bioventus Inc. (Nasdaq: BVS) (“Bioventus” or the “Company”), a global leader in innovations for active healing, has appointed Larry Chen as Managing Director, China and Asia Pacific. Chen has more than 20 years of experience in sales and marketing roles for leading health care companies with a presence in the region. Based in Shenzhen, China, he is responsible for significantly increasing penetration of Bioventus products across key markets, with a focus on China.

“We are glad to welcome Larry to Bioventus and look forward to leveraging his experience and relationships in both China, as we explore our expansion opportunities there, and throughout the Asia Pacific region,” said John Nosenzo, Chief Commercial Officer, Bioventus. “We believe patients and clinicians will benefit greatly from our solutions in osteoarthritic joint pain, minimally invasive trauma and bone graft substitutes.”

Chen joins Bioventus from Zipline Medical where for the past four years he served as its Director, Asia Pacific, until its acquisition by Stryker. Prior to that, Chen was Sales Director, and later Marketing Director, Greater China, for Smith & Nephew and served in regional sales and marketing roles in Asia for ArthoCare. His experience also includes Asia Pacific regional commercial leadership roles at Johnson & Johnson Medical/Ethicon, Mentor Corp. and Stryker, where he was based in California. Chen began his career as an Export Sales Manager at China Qing ’An International Trading in Beijing.

He received his MBA from the University of Leuven, now Vlerick Leuven Ghent School, and a Bachelor of Science in Economics from the University of International Business and Economics in Beijing.

About Bioventus
Bioventus delivers clinically proven, cost-effective products that help people heal quickly and safely. Its mission is to make a difference by helping patients resume and enjoy active lives. The Innovations for Active Healing from Bioventus include offerings for osteoarthritis, surgical and non-surgical bone healing. Built on a commitment to high quality standards, evidence-based medicine and strong ethical behavior, Bioventus is a trusted partner for physicians worldwide. For more information, visit www.bioventus.com and follow the Company on LinkedIn and Twitter.

Bioventus and the Bioventus logo are registered trademarks of Bioventus LLC.

Forward-Looking Statements
This press release contains forward-looking statements within the meaning of Section 27A of the Securities Act of 1933, as amended, and Section 21E of the Securities Exchange Act of 1934, as amended. All statements contained in this press release that do not relate to matters of historical fact should be considered forward-looking statements, including, without limitation, statements concerning our business strategy and operations and expected benefits and impact of Bioventus’ products in certain regions. In some cases, you can identify forward-looking statements by terminology such as “aim,” “anticipate,” “assume,” “believe,” “contemplate,” “continue,” “could,” “due,” “estimate,” “expect,” “goal,” “intend,” “may,” “objective,” “plan,” “predict,” “potential,” “positioned,” “seek,” “should,” “target,” “will,” “would” and other similar expressions that are predictions of or indicate future events and future trends, or the negative of these terms or other comparable terminology, although not all forward-looking statements contain these words. Forward-looking statements are inherently subject to risks and uncertainties, some of which cannot be predicted or quantified. Factors that could cause actual results to differ materially from those contemplated in this press release include, but are not limited to, statements about the adverse impacts on our business as a result of the COVID-19 pandemic; our dependence on a limited number of products; our ability to develop, acquire and commercialize new products, line extensions or expanded indications; the continued and future acceptance of our existing portfolio of products and any new products, line extensions or expanded indications by physicians, patients, third-party payers and others in the medical community; our ability to differentiate the hyaluronic acid (“HA”) viscosupplementation therapies we own or distribute from alternative therapies for the treatment of osteoarthritic; the proposed down-classification of non-invasive bone growth stimulators, including our Exogen system, by the FDA; our ability to achieve and maintain adequate levels of coverage and/or reimbursement for our products, the procedures using our products, or any future products we may seek to commercialize; our ability to complete acquisitions or successfully integrate new businesses, products or technologies in a cost-effective and non-disruptive manner; competition against other companies; the negative impact on our ability to market our HA products due to the reclassification of HA products from medical devices to drugs in the United States by the FDA; our ability to attract, retain and motivate our senior management and qualified personnel; our ability to continue to research, develop and manufacture our products if our facilities are damaged or become inoperable; failure to comply with the extensive government regulations related to our products and operations; enforcement actions if we engage in improper claims submission practices or in improper marketing or promotion of our products; the FDA regulatory process and our ability to obtain and maintain required regulatory clearances and approvals; failure to comply with the government regulations that apply to our human cells, tissues and cellular or tissue-based products; the clinical studies of any of our future products that do not product results necessary to support regulatory clearance or approval in the United States or elsewhere; and the other risks identified in the Risk Factors section of the Company’s public filings with the Securities and Exchange Commission (“SEC”), including Bioventus’ 424(b)(4) filed on February 12, 2021 in connection with the Company’s initial public offering, as such factors may be updated from time to time in Bioventus’ other filings with the SEC, which are accessible on the SEC’s website at www.sec.goc and the Investor Relations page of Bioventus’ website at ir.bioventus.com. Except to the extent required by law, the Company undertakes no obligation to update or review any estimate, projection, or forward-looking statement. Actual results may differ from those set forth in this press release due to the risks and uncertainties inherent in the Company’s business.

Media Contact:
Thomas Hill
919-474-6715
[email protected]

Investor Inquiries:
Mike Piccinino, CFA, IRC
Westwicke/ICR
[email protected]


Bioventus to Release Fourth Quarter and Fiscal Year 2020 Financial Results on March 25, 2021

DURHAM, NC – March 1, 2021 – Bioventus Inc. (Nasdaq: BVS) (“Bioventus” or the “Company”), a global leader in innovations for active healing, today announced that fourth quarter and fiscal year 2020 financial results will be released after the market closes on Thursday, March 25, 2021.

Management will host a conference call to discuss its financial results and provide a business update, with a question and answer session, at 5:00 p.m. Eastern Time on March 25, 2021. Those who would like to participate may dial 844-945-2085 (442-268-1266 for international callers) and provide access code 2158468. A live webcast of the call and any accompanying materials will also be provided on the investor relations section of the Company's website at https://ir.bioventus.com/.

The webcast will be archived on the Company’s website at https://ir.bioventus.com/ and available for replay until March 25, 2022.

About Bioventus
Bioventus delivers clinically proven, cost-effective products that help people heal quickly and safely. Its mission is to make a difference by helping patients resume and enjoy active lives. The Innovations for Active Healing from Bioventus include offerings for osteoarthritis, surgical and non-surgical bone healing. Built on a commitment to high quality standards, evidence-based medicine and strong ethical behavior, Bioventus is a trusted partner for physicians worldwide. For more information, visit www.bioventus.com and follow the company on LinkedIn and Twitter. Bioventus and the Bioventus logo are registered trademarks of Bioventus LLC.

Media Contact:
Thomas Hill
919-474-6715
[email protected]

Investor Inquiries:
Mike Piccinino, CFA, IRC
Westwicke/ICR
[email protected]


Bioventus Announces Pricing of Initial Public Offering

DURHAM, NC – February 10, 2021 – Bioventus Inc. ("Bioventus" or the “Company”) today announced the pricing of its initial public offering of 8,000,000 shares of Class A common stock at a public offering price of $13.00 per share. The Company’s Class A common stock is expected to begin trading on the Nasdaq Global Select Market under the symbol “BVS”, and the offering is expected to close on February 16, 2021, subject to customary closing conditions.

The underwriters have also been granted a 30-day option to purchase up to 1,200,000 additional shares of Class A common stock from Bioventus at the initial public offering price, less underwriting discounts and commissions.

The gross proceeds to the Company from the offering, before deducting the underwriting discounts and commissions and estimated offering expenses, are expected to be approximately $104.0 million (or $119.6 million if the underwriters exercise their option to purchase additional shares in full).

Morgan Stanley, J.P. Morgan Securities LLC and Goldman Sachs & Co. LLC are serving as joint lead book-running managers and as representatives of the underwriters for the proposed offering. Canaccord Genuity LLC is acting as lead manager for the offering.

The offering will be made only by means of a prospectus. A copy of the preliminary prospectus relating to the proposed offering may be obtained from any of the following sources:

  • Morgan Stanley & Co. LLC, Attention: Prospectus Department, 180 Varick Street, 2nd Floor, New York, NY 10014 or by email at [email protected];
  • J.P. Morgan Securities LLC, Attention: Broadridge Financial Solutions, 1155 Long Island Avenue, Edgewood, NY 11717, by telephone at 1-866-803-9204 or by email at [email protected]; or
  • Goldman Sachs & Co. LLC, Attention: Prospectus Department, 200 West Street, New York, NY 10282, by telephone at (866) 471-2526, or by email at [email protected].

A registration statement relating to these securities has been declared effective by the Securities and Exchange Commission ("SEC") on February 10, 2021. This press release shall not constitute an offer to sell or the solicitation of an offer to buy, nor shall there be any sale of these securities in any state or jurisdiction in which such an offer, solicitation or sale would be unlawful prior to registration or qualification under the securities laws of any such state or jurisdiction.

About Bioventus

Bioventus delivers clinically proven, cost-effective products that help people heal quickly and safely. Its mission is to make a difference by helping patients resume and enjoy active lives. The Innovations For Active Healing from Bioventus include offerings for osteoarthritis, surgical and non-surgical bone healing. Built on a commitment to high quality standards, evidence-based medicine and strong ethical behavior, Bioventus is a trusted partner for physicians worldwide.

SOURCE: Bioventus Inc.

Contacts:

Investors
Bioventus Investor Relations
[email protected] 

Media
Thomas Hill
[email protected]

 


Bioventus Announces Launch of Initial Public Offering

DURHAM, NC  –  February 4, 2021 – Bioventus Inc. ("Bioventus" or the “Company”), today announced that it has commenced the initial public offering of its Class A common stock. Bioventus is offering 7,350,000 shares of its Class A common stock. The initial public offering price is expected to be between $16.00 and $18.00 per share. Bioventus expects to grant the underwriters a 30-day option to purchase up to an additional 1,102,500 shares of its common stock at the initial public offering price to cover over-allotments. The shares are expected to trade on the Nasdaq Global Select Market under the ticker symbol “BVS.”

Morgan Stanley & Co. LLC, J.P. Morgan Securities LLC and Goldman Sachs & Co. LLC are serving as joint lead book-running managers and as representatives of the underwriters for the proposed offering. Canaccord Genuity LLC is acting as lead manager for the offering.

The offering will be made only by means of a prospectus. A copy of the preliminary prospectus relating to the proposed offering may be obtained from any of the following sources:

  • Morgan Stanley & Co. LLC, Attention: Prospectus Department, 180 Varick Street, 2nd Floor, New York, NY 10014 or by email at [email protected];
  • P. Morgan Securities LLC, Attention: Broadridge Financial Solutions, 1155 Long Island Avenue, Edgewood, NY 11717, by telephone at 1-866-803-9204 or by email at [email protected]; or
  • Goldman Sachs & Co. LLC, Attention: Prospectus Department, 200 West Street, New York, NY 10282, by telephone at (866) 471-2526, or by email at [email protected].

A registration statement on Form S-1 relating to these securities has been filed with the Securities and Exchange Commission but has not yet become effective. These securities may not be sold nor may offers to buy be accepted prior to the time the registration statement becomes effective.

This press release shall not constitute an offer to sell or the solicitation of an offer to buy these securities, nor shall there be any sale of these securities in any state or jurisdiction in which such offer, solicitation or sale would be unlawful prior to registration or qualification under the securities laws of any such state or jurisdiction.

Investors
Bioventus Investor Relations
[email protected]

Media
Thomas Hill
[email protected]


Miguel O. Beltrán-Delgado Joins Bioventus as Senior Vice President of Operations

DURHAM, NC – January 19, 2021 – Bioventus, a global leader in Innovations For Active Healing, has appointed Miguel O. Beltrán-Delgado as Senior Vice President of Operations. Miguel has more than 24 years of experience in operations, quality and manufacturing. He will be responsible for creating a vision for continual improvement of operations including driving productivity, reducing cycle times and optimizing the company’s manufacturing and supply chain footprint. Beltran will report to Bioventus CEO, Ken Reali and serve on the company’s executive leadership team.

“Miguel joins Bioventus at a pivotal time as we look to gain efficiencies and leverage economies of scale with our approach to operations and to support our growth,” said Reali. “His broad and deep background in healthcare manufacturing and experience in quality assurance, regulatory affairs and compliance line up well with our current portfolio of products and plans for future pipeline expansion.”

Beltran comes to Bioventus from CONMED where he served in several VP-level roles, most recently as Vice President, Advanced Engineering and Manufacturing. Prior to that, he was Head of Costa Rica Operations for Philips. He also served in leadership roles at Volcano Corporation and C. R. Bard. Beltran began his career with Raytheon and later worked in operations and quality roles for Stryker and Medtronic in Puerto Rico. He received a Bachelor of Science in Engineering cum laude from the University of Puerto Rico.

About Bioventus

Bioventus delivers clinically proven, cost-effective products that help people heal quickly and safely. Its mission is to make a difference by helping patients resume and enjoy active lives. The Innovations For Active Healing from Bioventus include offerings for osteoarthritis, surgical and non-surgical bone healing. Built on a commitment to high quality standards, evidence-based medicine and strong ethical behavior, Bioventus is a trusted partner for physicians worldwide. For more information, visit www.bioventus.com and follow the company on LinkedIn and Twitter.

Media Contact: Thomas Hill, 919-474-6715, [email protected]

Bioventus and the Bioventus logo are registered trademarks of Bioventus LLC.


Bioventus Receives Authorization to Proceed Under Investigational New Drug Application for Clinical Trial of Placental Tissue Particulate (PTP-001) for the Treatment of Knee OA

DURHAM, NC – November 18, 2020 – Bioventus, a leader in Solutions For Innovative Healing, received authorization to proceed under its investigational new drug (IND) application from the US Food and Drug Administration (FDA), allowing it to proceed to clinical trials of PTP-001. PTP-001 (commercial trade name MOTYS™) is a placental tissue particulate comprised of amnion, chorion and umbilical cord from full-term, healthy births and is provided sterile in micronized form.

Bioventus plans to evaluate the safety and efficacy of PTP-001 to treat osteoarthritis of the knee through an open-label, dose-escalation study. The study is expected to enroll 20 patients, 40-80 years of age and test two doses (low and high dose) of PTP-001 in two unique cohorts of 10 patients each. Each patient will receive a single injection of PTP-001.

“This submission and open IND for PTP-001, the first for Bioventus, is a monumental milestone in the history of our young company. We are proud of our submission team and are ready to begin enrolling patients and administering PTP-001 in Phase 1 of our study,” said Alessandra Pavesio, Senior Vice President and Chief Science Officer, Bioventus.

“This study will assess clinical safety of two doses of PTP-001, both at or higher than those often utilized today by physicians. Our goals are to begin to clarify the potential dose for PTP-001 and to determine whether PTP-001 could fulfill an unmet need for physicians and their patients with knee osteoarthritis,” she added.

About Bioventus
Bioventus delivers clinically proven, cost-effective products that help people heal quickly and safely. Its mission is to make a difference by helping patients resume and enjoy active lives. The Innovations For Active Healing from Bioventus include offerings for osteoarthritis, surgical and non-surgical bone healing. Built on a commitment to high quality standards, evidence-based medicine and strong ethical behavior, Bioventus is a trusted partner for physicians worldwide. For more information, visit www.bioventus.com and follow the company on LinkedIn and Twitter.

Media Contact: Thomas Hill, 919-474-6715, [email protected]

Bioventus and the Bioventus logo are registered trademarks and MOTYS is a trademark of Bioventus LLC.


Bioventus Appoints Chris Yamamoto Senior Vice President of Business Development and Strategy

DURHAM, NC – November 16, 2020 – Bioventus, a global leader in Innovations For Active Healing, has appointed Chris Yamamoto as Senior Vice President of Business Development and Strategy. Yamamoto brings nearly 20 years of experience in mergers & acquisitions and business development. He will be responsible for developing an inorganic growth strategy for the company and executing deals that will drive long-term value and further the company’s mission of helping patients regain active lifestyles. Yamamoto will report to Bioventus CEO, Ken Reali and will join the company’s executive leadership team.

“Chris is coming on board at an exciting time at Bioventus as we seek to accelerate growth and build scale and depth in our offerings through both organic and inorganic investment,” said Reali. “We are pleased to welcome Chris to the team. He is a highly respected leader in the global M&A community and I am confident he will make significant contributions to our ongoing success as we execute our growth and value creation strategy.”

Yamamoto joins Bioventus from Becton Dickinson and Company where he spent the last six years, most recently as Vice President and Managing Director of Corporate Development. Prior to Becton Dickinson, Yamamoto was a Vice President with The Blackstone Group. He also worked at Fox Paine, Thoma Cressey, UBS Investment Bank and other institutions. Yamamoto received a Bachelor of Arts in Economics cum laude from Williams College.

About Bioventus
Bioventus delivers clinically proven, cost-effective products that help people heal quickly and safely. Its mission is to make a difference by helping patients resume and enjoy active lives. The Innovations For Active Healing from Bioventus include offerings for osteoarthritis, surgical and non-surgical bone healing. Built on a commitment to high quality standards, evidence-based medicine and strong ethical behavior, Bioventus is a trusted partner for physicians worldwide. For more information, visit www.bioventus.com and follow the company on LinkedIn and Twitter.

Media Contact: Thomas Hill, 919-474-6715, [email protected]

Bioventus and the Bioventus logo are registered trademarks of Bioventus LLC.


Bioventus to Provide CVS Caremark with its Portfolio of Preferred Options for Knee Osteoarthritis Patients Seeking Pain Relief

DURHAM, NC – November 10 – Beginning January 1, 2021 Bioventus, a global leader in Innovations For Active Healing, will gain preferred access through the CVS Caremark Formulary, to DUROLANE®, GELSYN-3® and SUPARTZ FX®, for the treatment of knee osteoarthritis (OA) pain. CVS Caremark manages the drug benefits for more than 40 million lives, which includes the prescription drug benefits of 6 million Aetna members.

DUROLANE, is a single-injection, GELSYN-3, a three-injection, and SUPARTZ FX, a five-injection hyaluronic acid (HA)-based joint-fluid treatment for patients. All three products will be among the four preferred standard formulary options of knee OA treatments for CVS Caremark members.

“CVS Caremark members now have access to the broadest HA portfolio available to patients and physicians in the US,” said John Nosenzo, Chief Commercial Officer, Bioventus. “DUROLANE, GELSYN-3 and SUPARTZ FX, all from Bioventus, provide long lasting OA knee pain relief allowing patients to resume more active lives.”

About Bioventus
Bioventus delivers clinically proven, cost-effective products that help people heal quickly and safely. Its mission is to make a difference by helping patients resume and enjoy active lives. The Innovations For Active Healing from Bioventus include offerings for osteoarthritis, surgical and non-surgical bone healing. Built on a commitment to high quality standards, evidence-based medicine and strong ethical behavior, Bioventus is a trusted partner for physicians worldwide. For more information, visit www.bioventus.com and follow the company on LinkedIn and Twitter.

More information about the entire Bioventus portfolio of HA-based products is found at www.OAKneePainRelief.com.

Media Contact: Thomas Hill, 919-474-6715, [email protected]

Bioventus, the Bioventus logo, GELSYN-3 and DUROLANE are registered trademarks of Bioventus LLC. SUPARTZ FX is a registered trademark of Seikagaku Corp. CVS Caremark is a registered trademark of CVS Pharmacy, Inc.

S
ummary of Indications for Use:
DUROLANE is indicated for the treatment of pain in osteoarthritis of the knee in patients who have failed to respond adequately to conservative non-pharmacological therapy or simple analgesics, e.g. acetaminophen. Do not inject DUROLANE in patients with knee joint infections, skin diseases, or other infections in the area of the injection site. Do not administer to patients with known hypersensitivity or allergy to sodium hyaluronate preparations. Risks can include transient pain or swelling at the injection site. DUROLANE has not been tested in pregnant or lactating women, or children. Full prescribing information can be found in package insert, at www.DUROLANE.com, or by contacting Bioventus Customer Service at 1-800-836-4080.

GELSYN-3 is indicated for the treatment of pain in osteoarthritis of the knee in patients who have failed to respond adequately to conservative non-pharmacologic therapy and simple analgesics (e.g. acetaminophen). Do not administer to patients with known hypersensitivity (allergy) to sodium hyaluronate preparations. Do not inject GELSYN-3 into the knees of patients having knee joint infections or skin diseases or infections in the area of the injection site. GELSYN-3 is not approved for pregnant or nursing women, or children. Risks can include general knee pain, warmth and redness or pain at the injection site. Full prescribing information can be found in product labeling, at www.GELSYN3.com or by contacting customer service at 1-800-836-4080.

SUPARTZ FX is indicated for treatment of pain in osteoarthritis (OA) of the knee in patients who have failed to respond adequately to conservative non-pharmacologic therapy and simple analgesics, e.g., acetaminophen. You should not use SUPARTZ FX if you have infections or skin diseases at the injection site or allergies to avian (bird) products (feathers and eggs). SUPARTZ FX is not approved for pregnant or nursing women, or children. Risks can include general knee pain, warmth and redness or pain at the injection site. Full prescribing information can be found in product labeling, at www.SupartzFX.com or by contacting customer service at 1-800-836-4080.


Bioventus Reaches Milestone with 2 Million DUROLANE® Treatments Worldwide

DURHAM, NC – September 22, 2020 – Bioventus, a global leader in Innovations For Active Healing, is celebrating a milestone and recognizing more than 2 million treatments worldwide with DUROLANE, its single-injection, hyaluronic acid (HA) product used in the treatment of pain associated with osteoarthritis (OA). DUROLANE is the original single injection hyaluronic acid therapy, has helped patients in nearly 30 countries and is a trusted therapy for clinicians in the management of OA.

Proven safe and effective, DUROLANE has more clinical studies than any other US single-injection HA, and has also been proven to provide greater reduction in OA knee pain versus Synvisc-One®.1,2 It has longer lasting pain relief versus a steroid injection, is safe and repeated use of DUROLANE does not increase the incidence of adverse events.3,4 

DUROLANE is available in its original 3ml syringe for treatment of large joints and in a 1ml syringe, known as DUROLANE SJ, to enable treatment of small joints.* Both are produced using a natural, safe and proven technology called NASHA®. This process yields a high molecular weight stabilized HA, which is a naturally occurring molecule that provides lubrication and cushioning in a normal joint.

“The US launch of DUROLANE in 2018 boosted our growth to more than 2 million treatments and we are very proud of this milestone. Still, there are many more patients to reach,” said John Nosenzo, Chief Commercial Officer, Bioventus. “In the US, more than 14 million people are afflicted with knee OA and osteoarthritis overall affects more than 240 million globally.5,6 Returning people to active lifestyles is our commitment to the market and we are pleased that DUROLANE is serving the needs of clinicians and the OA patients they treat.”

About Bioventus
Bioventus delivers clinically proven, cost-effective products that help people heal quickly and safely. Its mission is to make a difference by helping patients resume and enjoy active lives. The Innovations For Active Healing from Bioventus include offerings for osteoarthritis, surgical and non-surgical bone healing. Built on a commitment to high quality standards, evidence-based medicine and strong ethical behavior, Bioventus is a trusted partner for physicians worldwide. For more information, visit www.bioventus.com and follow the company on LinkedIn and Twitter.

Media Contact: Thomas Hill, 919-474-6715, [email protected]

Bioventus, the Bioventus logo, and DUROLANE are registered trademarks of Bioventus LLC. NASHA is a registered trademark. Synvisc-One and Synvisc are registered trademarks of Genzyme Corporation.

*DUROLANE SJ is not available in the US.

Summary of Indication for Use: DUROLANE is indicated for the treatment of pain in osteoarthritis (OA) of the knee in patients who have failed to respond adequately to conservative non-pharmacological therapy or simple analgesics, e.g. acetaminophen. Do not inject DUROLANE in patients with knee joint infections, skin diseases, or other infections in the area of the injection site. Do not administer to patients with known hypersensitivity or allergy to sodium hyaluronate preparations. Risks can include transient pain or swelling at the injection site. DUROLANE has not been tested in pregnant or lactating women, or children. Full prescribing information can be found in product labeling, at www.DUROLANE.com, or by contacting Bioventus Customer Service at 1-800-836-4080.

NOTE: The above indications presented are for the US market; indications may vary by country. Contact your local Bioventus representative or visit www.durolane.com/uk/selection for prescribing information specific to your market.

  1. McGrath AF, McGrath AM, Jessop ZM, et al. A comparison of intra-articular hyaluronic acid competitors in the treatment of mild to moderate knee osteoarthritis. J Arthritis. 2013; 2(1):108. doi:10.4172/2167-7921.1000108. 2. DOF RPT-001111 3. Leighton R, Åkermark C, Therrien R, et. al. NASHA hyaluronic acid vs methylprednisolone for knee osteoarthritis: a prospective, multi-centre, randomized, non-inferiority trial. Osteoarthritis Cartilage. 2014; 22(1):17-25. 4. DUROLANE [package insert]. Durham, NC: Bioventus LLC; 2017. 5. Arthritis Foundation. What is osteoarthritis? Accessed February 9, 2019. www.arthritis.org/about-arthritis/types/osteoarthritis/what-is-osteoarthritis.php 6. Hawker GA. Osteoarthritis is a serious disease. Clin Exp Rheumatol. 2019;37 Suppl 120(5):3-6.

Bioventus Reports First Use of its SIGNAFUSE Bioactive Bone Graft in Strip Format

DURHAM, NC – September 2, 2020 – Bioventus is sharing results of the first in-patient use of its new SIGNAFUSE Bioactive Bone Graft strips. Rick Placide, M.D. of VCU Health in Richmond, VA, performed a posterolateral lumbar fusion (PLF) and placed the SIGNAFUSE strips in the posterolateral gutters of the patient’s spine.

“Since the recent release of the SIGNAFUSE strip, we have used it as a bone graft extender in several cases and found it easy to use,” remarked Dr. Placide. “We have already been impressed by its ability to absorb bone marrow aspirate while maintaining its form, flexibility and toughness. These properties make SIGNAFUSE strips ideal for a variety of cases, including spanning large defects. We look forward to following the clinical outcomes.”

SIGNAFUSE strips were designed with the patient in mind. They come in multiple sizes ranging from 25 to 200 millimeters in length, allowing utilization over multiple levels like we saw in Dr. Placide’s deformity application case,” said Lawrence Boyd PhD, Vice President, Product Development, Bioventus. “There are benefits for the surgeon as well: these strips hydrate rapidly and provide exceptional handling properties for intraoperative flexibility.”

100mm-SIGNAFUSE-Strips-used-on-each-side-of-a-4-level-posterolateral-lumbar-fusion.

The new strip format of SIGNAFUSE is available now from Bioventus distributors nationwide.

About Bioventus

Bioventus delivers clinically proven, cost-effective products that help people heal quickly and safely. Its mission is to make a difference by helping patients resume and enjoy active lives. The orthobiologic products from Bioventus include offerings for osteoarthritis, surgical and non-surgical bone healing. Built on a commitment to high quality standards, evidence-based medicine and strong ethical behavior, Bioventus is a trusted partner for physicians worldwide. For more information, visit www.bioventus.com and follow the company on LinkedIn and Twitter.

Media Contact: Thomas Hill, 919-474-6715, [email protected]

Bioventus, the Bioventus logo and SIGNAFUSE are registered trademarks of Bioventus LLC.

Summary of Indications for Use
SIGNAFUSE Bioactive Bone Graft is a bone graft substitute intended for use in bony voids or gaps of the skeletal system not intrinsic to the stability of the bony structure. These osseous defects may be surgically created or result from traumatic injury to the bone. SIGNAFUSE Bioactive Bone Graft is indicated to be combined with autologous bone marrow aspirate and packed into osseous defects of the extremities, pelvis and posterolateral spine. When used in the posterolateral spine, SIGNAFUSE Bioactive Bone Graft is to be used as an autograft extender. The device resorbs and is replaced by host bone during the healing process.